Basic Fibroblast Growth Factor Induced Angiogenesis and Prefabricated Flap Survival

Melinda J. Haws; Detlev Erdman; Semira Bayati; Richard E. Brown; Robert C. Russell

doi:10.1055/s-2001-12687

Journal of Reconstructive Microsurgery, Table of Contents

J Reconstr Microsurg 2001; 17(1): 039-044
DOI: 10.1055/s-2001-12687

Basic Fibroblast Growth Factor Induced Angiogenesis and Prefabricated Flap Survival

Melinda J. Haws¹ , Detlev Erdman² , Semira Bayati² , Richard E. Brown² , Robert C. Russell²

¹Microsurgery and Hyperbaric Laboratory, Division of Plastic Surgery, University of Nevada School of Medicine, Las Vegas, Nevada
²Institute for Plastic and Reconstructive Surgery, Department of Surgery, Southern Illinois University School of Medicine, Springfield, Illinois

Abstract

ABSTRACT

Prefabrication of a latissimus dorsi myocutaneous flap was performed in adult male Landrace pigs. Gelfoam sponges were used as a delivery system for basic fibroblast growth factor (bFGF) at the muscle-subcutaneous tissue interface. Skin survival and angiogenesis were augmented in the growth-factor-treated animals. These data support the use of basic fibroblast growth factor to enhance flap prefabrication.

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References

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